Apigenin is a bioflavonoid compound (specifically a flavone) which is found in a wide variety of plants and herbs. It is highly abundant in chamomile, and may possess anxiety-reducing effects when consumed. At even higher doses, it may have sedative effects.

 

The calming effect of Apigenin is partially due to its ability to bind the GABAA receptor and act as a partial modulator. It likely potentiates (and is potentiated by) other flavonoids due to its complex CYP enzyme interactions in the liver. Apigenin also is known for its mood-boosting effects and some studies indicate it may normalize the ERK/CREB/BDNF pathway and enhance BDNF expression in certain cases. This may account for some of its cognition-enhancing effects.

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